Description
Product Characteristics: The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor of 45 kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding G-protein-dependent cellular responses are initiated 2+ such as increased intracellular Ca, granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.
Target Information: Please see product details or send an inquiry to antibodies-online for additional target information