Fig 1: Mucosal OSM and OSMR levels in postoperative patients with CD and serum OSM in postoperative patients with CD and multiple-affected families with IBD. A-B, Boxplots of mucosal OSM and OSMR as measured by microarray technologies (RMA values). C and D, Boxplots of serum OSM as measured by the OLINK proximity extension technology (NPX values). E and F, ROC analysis classifying (D) postoperative CD with and without recurrence or (F) unaffected FDRs of patients with IBD and members of control families without IBD based on serum OSM levels and fCal. Significant comparisons are highlighted in bold. fCal indicates fecal calprotectin; M6, six months after surgery; NPX, normalized protein expression values; RMA, robust multichip average.
Fig 2: Mucosal OSM and OSMR levels and serum OSM in newly diagnosed patients with IBD. A, OSM signals via a receptor complex composed of the gp130 co-receptor and either OSMR or LIFR. B-C, Boxplots of mucosal OSM and OSMR as measured by RNA sequencing (normalized counts). D, Boxplots of serum OSM as measured by the OLINK proximity extension technology (NPX values). Significant comparisons are highlighted in bold. NPX indicates normalized protein expression values.
Fig 3: Mucosal OSM and OSMR levels and serum OSM in newly diagnosed patients with IBD depending on disease prognosis and in patients with IBD initiating anti-TNF or vedolizumab therapy. A-B, D-E, G-H. Boxplots of mucosal OSM and OSMR as measured by RNA sequencing (normalized counts). C, F, I, Boxplots of serum OSM as measured by the OLINK proximity extension technology (NPX values). Significant comparisons are highlighted in bold. NPX indicates normalized protein expression values.
Fig 4: Immunohistochemical localization of OSM in the intestinal mucosa. Immunohistochemical staining of resected normal colon from a control patient without IBD (A and B), resected colonic tissue from a patient with IBD (C: UC; D: CD), resected normal ileum from a control patient without IBD (E and F), and resected ileal tissue from a patient with CD (G and H) undergoing surgery. Original magnification ×50 (C), ×100 (A, D, E, H), ×200 (G), and ×400 (B and F).
Supplier Page from Abcam for Anti-Oncostatin M/OSM antibody