Fig 1: Microengraving shows greater infiltration by IL-17A and IFN-? producing cells in the salivary glands of SjSS mice. Quantification of T lymphocytes isolated from the major salivary gland of B6 male (?), B6 female (?), B6.NOD-Aec1Aec2 male (), and B6.NOD-Aec1Aec2 female () mice expressing (a) CD4+IFN-?+, (b) CD8+IFN-?+, (c) CD4+IL-17A+, (d) CD8+IL-17A+, (e) CD4+IFN-?+IL-17A+, or (f) CD8+IFN-?+IL-17A+. The frequency in percentage of was determined by using the percentage (multiplied by 100) of the total number of CD4+IFN-?+ (Th1), CD4+IL-17A+ (Th17), CD8+IFN-?+ (Tc1), CD8+ IL-17A+ (Tc17), CD4+IL-17A+IFN-?+ (Th17/1), and CD8+IL-17A+IFN-?+ (Tc1/17) cells from wells with single live cells among the total number of wells with single CD4+ or CD8+ cells. Group comparisons were made using a Kruskall-Wallis test with Dunn’s post hoc test. Statistical significance was defined as a p value < 0.05. All results are presented as means ± s.e.m. Significance was determined as *p < 0.05, **p < 0.01.