Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] ab76316 from Abcam

Product Specs
ItemAnti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab76316
Antibody TypePrimary
HostRabbit
IsotypeIgG
CloneEPR2425Y
ClonalityMonoclonal
Conjugate/TagUnconjugated
ApplicationsElectron Microscopy, Flow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunohistochemistry (Frozen sections), Western blot, Electron Microscopy, Flow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunohistochemistry (Frozen sections), Western blot
Quantity10 UL, 100 UL
Research AreaNeuroscience
Gene NameGRM5
ReactivityHuman, Mouse, Rat
TargetMetabotropic Glutamate Receptor 5

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Lipid metabolism marker CD36 is associated with 18FDG-PET/CT false negative lymph nodes in head and neck squamous cell carcinomaFrontiers in OncologyMay 3, 2023Xiaoyan Meng, Jingjing Sun, Feng Xu, Zhonglong Liu, Yue Heand incubated overnight at 4°C with primary antibodies against GLUT1 (ab115730, 1:250, Abcam), GLUT5 (ab76316, 1:250, Abcam), GLS (ab156876, 1:100, Abcam), SLC1A5 (ab237704, 1:1000, Abcam), CPT1A (ab234111, 1:1000,

(2) Hodgkin Lymphoma Cell Lines and Tissues Express mGluR5: A Potential Link to Ophelia Syndrome and Paraneoplastic Neurological DiseaseCellsFebruary 13, 2023Sofia Schnell, Ellen Knierim, Petra Bittigau, Jakob Kreye, Kathrin Hauptmann, Patrick Hundsdoerfer, Susanne Morales-Gonzalez, Markus Schuelke, Marc Nikolausbovine serum albumin for 1 h at RT and incubated with the primary antibodies against mGluR5 (1:250, Cat# ab76316, Abcam, Cambridge, UK) and CD30 (1:80, Ber-H2, Cat# M0751, Dako, Jena, Germany) O/N at 4°C. Secondary

(3) Identification of Kv4.2 protein complex and modifications by tandem affinity purification-mass spectrometry in primary neuronsFrontiers in Cellular NeuroscienceDecember 9, 2022Jia-Hua Hu, Ying Liu, Dax A. Hoffmanmouse anti-GluN2B (NeuroMab, 75–097) was used at 1:200 for immunostaining; rabbit anti-mGluR5 (Abcam, ab76316) was used at 1:100 for immunostaining; Myc (Millipore, 05–419) was used at 1:5,000 for western blot;

(4) The Anti-Inflammatory Effect of Preventive Intervention with Ketogenic Diet Mediated by the Histone Acetylation of mGluR5 Promotor Region in Rat Parkinson’s Disease Model: A Dual-Tracer PET StudyParkinson's DiseaseSeptember 5, 2022Yuankai Zhu, Xiangyu Tang, Zhaoting Cheng, Qingjian Dong, Ge Ruanhemisphere. Immunofluorescent staining was performed with the primary antibodies against mGluR5 (1 : 200, ab76316, Abcam), TSPO (1 : 100, ab154878, Abcam), ionized calcium–binding adaptor molecule-1 (Iba-1) for microglia

(5) Effects of Dietary n-3 LCPUFA Supplementation on the Hippocampus of Aging Female Mice: Impact on Memory, Lipid Raft-Associated Glutamatergic Receptors and NeuroinflammationInternational journal of molecular sciencesJuly 4, 2022Taoro-González L, Pereda D, Valdés-Baizabal C, González-Gómez M, Pérez JA, Mesa-Herrera F, Canerina-Amaro A, Pérez-González H, Rodríguez C, Díaz M, et al.(Anti-Flotillin 1, 1:1000, ab41927; Anti-ERα 1:200, sc-542; Anti-Metabotropic Glutamate Receptor 5, 1:1000, ab76316; Anti-GluN2B, 1:1000, ab65783; and anti-GluA1, 1:1000, ab109450) overnight at 4 °C, followed by incubation

(6) mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor LearningCellsJune 23, 2022Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aibamembrane (Millipore, Billerica, MA, USA). The membrane was incubated with anti-mGluR5 antibody (1:5000, ab76316, Abcam, Cambridge, UK) and β-actin (1:1000, AC-74, Sigma-Aldrich, St. Louis, MO, USA) followed by anti-rabbit

(7) Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in MiceLife (Basel)March 21, 2022Ana Elena Teleuca et al.part of the membrane was probed with a polyclonal anti-mGlu5 receptor (Abcam, Waltham, MA, USA, Cat. AB76316, dilution 1:5.000), anti-norbin antibody (Abcam, Waltham, MA, USA, Cat. AB88877, dilution 1:700) or

(8) Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neuronsProtein & cellJuly 1, 2021Liang D, Xue Z, Xue J, Xie D, Xiong K, Zhou H, Zhang F, Su X, Wang G, Zou Q, et al.for immunocytochemistry, NB110-39033SS, Novus), mGluR5 (1:50 for immunohistochemistry, 1:100 for immunocytochemistry, ab76316, Abcam), VGLUT1 (1:50 for immunohistochemistry, 48-2400, Invitrogen; 1:100 for immunocytochemistry,

(9) Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampusProgress in neuro-psychopharmacology & biological psychiatryJanuary 10, 2021Elhussiny MEA, Carini G, Mingardi J, Tornese P, Sala N, Bono F, Fiorentini C, La Via L, Popoli M, Musazzi L, et al.Millipore), mGlu1 (1:1000, cod. Ab82211, Abcam), mGlu2 (1:1000, cod. Ab106811, Abcam), mGlu5 (1:1000, cod. Ab76316, Abcam). Mouse monoclonal anti-GAPDH (1:40.000, cod. Mab374, Millipore) or rabbit monoclonal anti-β-Actin

(10) Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male miceJournal of neurochemistryJanuary 1, 2021Bhat SA, Henry RJ, Blanchard AC, Stoica BA, Loane DJ, Faden AI.was from Sigma-Aldrich (St. Louis, MO). Primary antibodies were purchased as indicated: anti-mGluR5 (#ab76316, RRID:AB_1523944), anti-GFAP (#ab7260, RRID:AB_305808) from Abcam (Eugene, OR); anti-p65NFкB (#8242;

(11) Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory SynapseThe Journal of NeuroscienceSeptember 9, 2020Kang Peng, Xiaoyu Wang, Yuan Wang, Dainan Li, Hai Huang, Yong Lusections were immunocytochemically double stained for antimGluR5 (1:1000; rabbit monoclonal, catalog #ab76316, Abcam; RRID: AB_1523944) or anti-mGluR5 (1:500; rabbit polyclonal, catalog #ab5675, Millipore; RRID:AB_2295173),

(12) Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal GlandsFrontiers in physiologyJanuary 1, 2020Fan YN, Li C, Huang L, Chen L, Tang Z, Han G, Liu Y.primary antibodies, including anti-mGluR1 (1:200, ab82211, Abcam) and anti-mGluR5 antibodies (1:200, ab76316, Abcam), were added to the sections, followed by incubation overnight at 4°C. Negative controls were

(13) Retinal alterations in a pre-clinical model of an autism spectrum disorderMolecular AutismDecember 1, 2019Elisa Maria Guimarães-Souza, Christina Joselevitch, Luiz Roberto G. Britto, Silvana Chiavegatto#/company,Species,Dilution Anti-beta-actin,A5316,Mouse,1:50000 (WB) Anti-synapsin-1 (SYN-1),AB1543/Millipore,Rabbit,1:500 (IHC); 1:5000 (WB) Anti-mGluR5,ab76316/Abcam,Rabbit,1:200 (IHC); 1:1000 (WB) Anti-FMRP,ab17722/Abcam,Rabbit,1:200 (IHC); 1:1000 (WB) Anti-GABA,A2052/Sigma,Rabbit,1:1000

(14) Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulationTranslational PsychiatryDecember 1, 2019Chi Ho Chong, Qi Li, Priscilla Hoi Shan Mak, Cypress Chun Pong Ng, Eva Hin Wa Leung, Vicky Huiqi Tan, Anthony Kin Wang Chan, Grainne McAlonan, Siu Yuen Chanwere loaded for western blot analysis. Proteins were detected with antibodies for mGluR5 (Abcam, cat. AB76316) and β-tubulin (Sigma, cat. T8328). Signal intensities were quantitated with ImageJ and normalized with

(15) Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic SteatosisCell metabolismNovember 5, 2019Choi WM, Kim HH, Kim MH, Cinar R, Yi HS, Eun HS, Kim SH, Choi YJ, Lee YS, Kim SY, et al.,Thermo Fisher Scientific,Cat#:PA5–16581; RRID: AB_10977936 NRF2,Abcam,Cat#:ab31163; RRID: AB_881705 mGluR5,Abcam,Cat#:ab76316; RRID: AB_1523944 GS,Abcam,Cat#: ab73593; RRID: AB_2247588 GLS2,Abcam,Cat#; ab113509; RRID: AB_10866157 "Anti-rabbit

(16) Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomasBMC cancerSeptember 18, 2019Engqvist H, Parris TZ, Kovács A, Nemes S, Werner Rönnerman E, De Lara S, Biermann J, Sundfeldt K, Karlsson P, Helou K.,Thermo Fisher,- GID4,EC,OS,1.04,1.02–1.07,0.0013,0.79,0.75,HPA044348,Sigma-Aldrich,1:150 GPR158,MC,OS,1.44,1.02–2.04,0.0380,0.77,4.93,HPA013185,Sigma-Aldrich,1:25 GRM5,EC,OS,0.56,0.35–0.91,0.0179,0.73,−4.17,ab76316,Abcam,- IGHG1,CCC,DSS,1.20,1.04–1.39,0.0128,0.72,7.40,SAB1401207,Sigma-Aldrich,1:25 JCHAIN,CCC,OS,1.23,1.04–1.46,0.0133,0.73,6.34,HPA044132,Sigma-Aldrich,- KIF26B,EC,DSS,0.46,0.23–0.91,0.0248,0.91,−3.68,HPA027709,Sigma-Aldrich,- MAP7D2,MC,OS,1.86,1.09–3.16,0.0218,0.83,4.06,HPA051508,Sigma-Aldrich,- MTRNR2L1,HGSC,OS,1.23,1.08–1.40,0.0017,0.64,5.68,HPA059729,Sigma-Aldrich,- MUC15,EC,OS,0.66,0.50–0.87,0.0032,0.79,−5.33,HPA026110,Sigma-Aldrich,- PITHD1,CCC,DSS,146.53,6.19–3470,0.0020,0.89,0.57,PAB20914,Abnova,1:50 PTEN,EC,DSS,404.90,"1.23–133,809",0.0425,0.96,0.99,ab109454,Abcam,1:100 RTKN2,MC,OS,7.87,1.48–41.96,0.0157,0.89,1.66,"17,458–1-AP",Nordic

(17) mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 ReceptorsScientific ReportsDecember 1, 2018Serena Notartomaso et al.Santa Cruz Biotechnology, Dallas, TX, Cat #sc-7691, lot. G2512), anti-mGlu5 receptor (1:200, Abcam, Cat #AB76316, lot. GR45647-18) and anti-mGlu1α receptor (1:100, BD Biosciences, Cat #556389, lot. 3172791). Sections

(18) AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for ImmunotherapyMolecular NeurobiologyOctober 1, 2018A. Borreca et al.(mGluR2) antibody rabbit 07-261, Millipore; metabotropic glutamate receptor 5 (mGluR5) antibody (EPR2425Y) rabbit ab76316, Abcam; NMDAζ1 antibody (C-20) goat sc-1467, Santa Cruz; PSD95 antibody (clone 7E3-1B8) mouse Mol

(19) mGluR5 mediates post-radiotherapy fatigue development in cancer patientsTranslational psychiatryMay 30, 2018Feng LR, Fernández-Martínez JL, Zaal KJM, deAndrés-Galiana EJ, Wolff BS, Saligan LN.probed with an anti-metabotropic glutamate receptor 5 antibody [EPR2425Y] (mGluR5, catalog number: ab76316; Abcam, Cambridge, MA). Antibody:antigen complexes were visualized with Alexa Fluor 568-conjugated goat

(20) Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout micePsychopharmacologyMay 1, 2017Higa KK, Grim A, Kamenski ME, van Enkhuizen J, Zhou X, Li K, Naviaux JC, Wang L, Naviaux RK, Geyer MA, et al.antibodies overnight in a cold room using anti-mGluR1 (#ab27199 from Abcam, Cambridge, MA), mGluR5 (#ab76316 from Abcam), and dopamine D4 receptor (#ADR-004, from Alomone Labs, Jerusalem, Israel) antibodies. After

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9/8/2017A Good Antibody To Detect GRM5 (MGluR5) In Rat Christopher WardWe wanted to confirm that our rats carrying a mutation in the Grm5 locus showed decreased expression of Grm5. We tested frontal cortex samples from wildtype and Grm5-heterozygous mutant rats. This ... Read Review

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] from Abcam

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Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y] from Abcam

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