Anti-beta 2 Microglobulin antibody [EP2978Y] ab75853 from Abcam

Product Specs
ItemAnti-beta 2 Microglobulin antibody [EP2978Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab75853
Antibody TypePrimary
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western blot
Conjugate/TagUnconjugated
CloneEP2978Y
HostRabbit
Quantity10 UL, 40 UL, 100 UL
ClonalityMonoclonal
IsotypeIgG
Research AreaImmuno-oncology
Gene NameB2M
ValidationKnockOut Validated
ReactivityHuman, Mouse, Rat
Targetbeta 2 Microglobulin

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancerFrontiers in OncologyOctober 13, 2023Ilaria Nesi, Chiara Della Bella, Maria Letizia Taddei, Alice Santi, Erica Pranzini, Paolo Paoli, Mario Milco D’Elios, Matteo Ramazzotti, Massimo Genovese, Anna Caselli, et al.(polyclonal) (PA5115364) was obtained from Thermo Fischer Scientific. Anti β2-microglobulin (EP2978Y) (ab75853) was from Abcam. Ovalbumin peptide (257–264) was purchased from Sigma-Aldrich, and ovalbumin was purchased

(2) Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapyJ NanobiotechnologyAugust 8, 2023Xianming Wang, Yu Cai, Cuixi Wu, Jiamin Liang, Kangning Tang, Zefeng Lin, Lingling Chen, Yao Lu, Qing Wangwere from Sigma-Aldrich (USA). Antibodies against p16ink4a (polyclonal, ab108349), B2M (monoclonal, ab75853), high mobility group protein 1 (HMGB-1) (ab228624), matrix metalloprotein 13 (MMP-13) (ab39012), and

(3) cGAS-STING drives ageing-related inflammation and neurodegenerationNatureAugust 2, 2023Muhammet F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, Selene Glück, Vivek V. Thacker, Lucie Favre, Bastien Mangeat, Lona J. Kroese, et al.Z033429-2(AGI), 1:100; NeuN, Merck, MAB377, 1:100; synaptophysin, Cell Signaling, 36406S, 1:500; and B2M, Abcam, ab75853, 1:100) overnight at 4 °C. For immunofluorescence analysis, the sections were then stained with fluorescently

(4) Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell Line hCMEC/D3CellsJune 27, 2023Roberto Berra-Romani, Valentina Brunetti, Giorgia Pellavio, Teresa Soda, Umberto Laforenza, Giorgia Scarpellino, Francesco Moccia(#161-0376, Bio-Rad Laboratories, Hercules, CA, USA). Anti-β2-microglobulin (B2M) rabbit monoclonal (ab75853, 1:10,000; Abcam, Cambridge, UK) was used on the stripped membrane [12]. Protein bands were detected

(5) A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cellsJournal of Cell BiologyDecember 5, 2022Hui Jing Lim, Jacinta M. Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey Y.W. Mak, Abderrahman Hachani, Regan J. Anderson, Gavin F. Painter, Jesse Goyette, et al.immunofluorescence/PLA: mouse anti-MR1 mAb (clone 8G3 [McWilliam et al., 2020]) and rabbit anti-β2m (product ab75853; Abcam). For detection of AP2 proteins: mouse anti-AP2A1 (clone 8/Adaptin a; BD), rabbit anti-AP2A1

(6) Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancerNature CommunicationsDecember 1, 2022Joyce V. Lee et al.(1:1,000, clone Y69, ab32072, Abcam), anti-STAT1 (1:1,000, #9172, Cell Signaling), anti-B2M (1:10,000, ab75853, Abcam), Anti-Rabbit IgG (1:10,000, #7074, Cell Signaling). Uncropped and unprocessed scans of blots

(7) Cerium Oxide Nanoparticles Regulate Oxidative Stress in HeLa Cells by Increasing the Aquaporin-Mediated Hydrogen Peroxide PermeabilityInternational Journal of Molecular SciencesSeptember 16, 2022Giorgia Pellavio, Patrizia Sommi, Umberto Anselmi-Tamburini, Maria Paola DeMichelis, Stefania Coniglio, Umberto Laforenzamolecular weight markers (ab116028, Abcam, Cambridge, UK). Anti-β-2-microglobulin rabbit monoclonal (ab75853, 1:10000; Abcam, Cambridge, UK) was used on the stripped membrane [60]. Protein bands were detected

(8) A Novel Proteogenomic Integration Strategy Expands the Breadth of Neo-Epitope SourcesCancers (Basel)June 19, 2022Haitao Xiang et al.against HLA class I A/B/C (# ab1262377, Abcam, Cambridge, UK), GAPDH (#ab181602, Abcam), and β2M (# ab75853, Abcam) were used. Detection was performed using horseradish peroxidase-labeled goat anti-rabbit IgG (H + L

(9) Aquaporin-6 May Increase the Resistance to Oxidative Stress of Malignant Pleural Mesothelioma CellsCellsJune 10, 2022Giorgia Pellavio, Simona Martinotti, Mauro Patrone, Elia Ranzato, Umberto Laforenza(AB-81599, 1:2000; Immunological Sciences, Rome, Italy) or anti-β-2-microglobulin rabbit monoclonal (ab75853, 1:10000; Abcam, Cambridge, UK) diluted in blocking solution. Densitometry was performed by acquiring

(10) Nucleolin-SLe ^A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer CellsSSRN Electronic JournalApril 3, 2022Elisabete Fernandes et al.Biologicals, Centennial, CO, USA Sigma-Aldrich, St. Louis, MO, USA Abcam, Cambridge, UK NB100-2866 A1978 ab75853 Polyclonal Monoclonal Monoclonal AC-15 EP2978Y Rabbit Mouse Rabbit WB WB WB Anti-CA19.9 (SLeA) Abcam,

(11) Lipopolysaccharide-Induced Strain-Specific Differences in Neuroinflammation and MHC-I Pathway Regulation in the Brains of Bl6 and 129Sv MiceCellsMarch 18, 2022Maria Piirsalu, Keerthana Chithanathan, Mohan Jayaram, Tanel Visnapuu, Kersti Lilleväli, Mihkel Zilmer, Eero VasarProtein,Host,Dilution,Company,Catalog No Beta 2 microglobulin (β2m),Rabbit,"1:10,000",Abcam,ab75853 Tapasin (TapBP),Rabbit,1:1000,Abcam,ab196764 Angiotensin Converting Enzyme 1 (ACE),Rabbit,"1:10,000",Abcam,ab254222 B-actin,Mouse,"1:10,000",Santa Cruz Biotechnology

(12) Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling AxisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)March 1, 2022Xiong W, He W, Wang T, He S, Xu F, Wang Z, Wang X, Guo H, Ling J, Zhang H, et al.anti‐SMAD4 (CST, 46535), anti‐STING (CST, 13647), anti‐RAD51 (CST, 8875), anti‐β2‐microglobulin (Abcam, ab75853), anti‐IRF3 (CST, 4302), anti‐phosphorylated‐IRF3 (CST, 29047), anti‐TBK1 (CST, 13504), anti‐phosphorylated‐TBK1

(13) Downregulation of MARC2 Promotes Immune Escape and Is Associated With Immunosuppression of Hepatocellular CarcinomaFrontiers in GeneticsJanuary 31, 2022Dehai Wu, Shuhang Liang, Hongrui Guo, Shugeng Zhang, Guangchao Yang, Yubin Yuan, Lianxin Liuchemiluminescence kit. Antibodies against MARC2 (ab224097), PPARA (ab126285), HLA-C (ab126722), and B2M (ab75853) were obtained from Abcam. Statistical Analysis R studio and GraphPad Prism 7 were used for the statistical

(14) Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasionTheranosticsJanuary 1, 2022Gaiteiro C, Soares J, Relvas-Santos M, Peixoto A, Ferreira D, Paulo P, Brandão A, Fernandes E, Azevedo R, Palmeira C, et al.RT for analysis of Tn expression. Detection of B2M with the recombinant anti-B2M antibody [EP2978Y] (ab75853, Abcam; Table S2) followed by incubation with goat anti-rabbit IgG (H+L) HPR conjugate antibody (1:60,000;

(15) Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H2O2 Permeability: New Tools for Counteracting Oxidative StressInternational Journal of Molecular SciencesSeptember 10, 2021Giorgia Pellavio, Giacomo Rossino, Giulia Gastaldi, Daniela Rossi, Pasquale Linciano, Simona Collina, Umberto Laforenzastripped following Yeung and Stanley [58] and reprobed with anti β-2-microglobulin (B2M) rabbit antibody (ab75853, Abcam, Cambridge, UK) diluted 1:10,000 in blocking solution. Densitometry was performed by acquiring

(16) Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axisJournal for ImmunoTherapy of CancerJune 10, 2021Mayu Sun, Pengfei Gu, Yang Yang, Luodan Yu, Zheshun Jiang, Jingquan Li, Yingying Le, Yu Chen, Qian Ba, Hui WangAPC-CD206 (141707; Biolegend). The anti-mouse antibodies used for immunobloting were anti-B2m antibody (ab75853; Abcam); anti-TLR4 antibody (14358; CST); anti-TRAF6 antibody (ab33915; Abacam); anti-MYD88 antibody

(17) Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s diseaseNature NeuroscienceJune 1, 2021Kelly A. Zalocusky et al.Santa Cruz Biotech, 1:200), p-Tau (PHF1, gift from Peter Davies, 1:600), t-Tau (T6402, Sigma, 1:350), B2M (ab75853, Abcam, 1:5000), and Beta-III-Tubulin (PRB435P, Covance, 1:20,000). The secondary antibodies were IgG

(18) CRISPR-edited megakaryocytes for rapid screening of platelet gene functionsBlood advancesMay 11, 2021Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, et al.(CalDAG-GEF1) (RASGRP2) (Genetex #GTX108616), aIIb (Santa Cruz #166599), GP6 (R&D Systems #AF3627), B2M (Abcam #Ab75853), COMMD7 (Novus Biologicals #NBP2-58399), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Santa Cruz

(19) Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cellsPLoS neglected tropical diseasesMarch 1, 2021Xu P, Gao J, Shan C, Dunn TJ, Xie X, Xia H, Zou J, Thames BH, Sajja A, Yu Y, et al.antibodies (1:100, sc-1668, Santa Cruz Biotechnology); anti-beta 2 Microglobulin rabbit antibodies (1:4000, ab75853, Abcam, Cambridge, UK). Anti-GAPDH mouse antibodies (1:1,000, ab8245, Abcam) were used as internal controls.

(20) IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factorsThe EMBO journalNovember 16, 2020Bevington SL, Keane P, Soley JK, Tauch S, Gajdasik DW, Fiancette R, Matei-Rascu V, Willis CM, Withers DR, Cockerill PN.p‐STAT5 (Y694) (Cell signaling #9351S) STAT5 (Santa Cruz #sc‐835X), RUNX1 (Abcam #ab23980), B2M (Abcam #ab75853), and ETS1 (Santa Cruz #sc‐350X). Membranes were washed with TBST and incubated with 1:10,000 dilution

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Anti-beta 2 Microglobulin antibody [EP2978Y] from Abcam

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Anti-beta 2 Microglobulin antibody [EP2978Y] from Abcam

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