Fig 2: TDG was a target of miR-107 and was increased by HOTAIRM1 overexpression.a Online bioinformatics software tools predicted a putative binding site between miR-107 and the 3'-UTR of TDG. This binding site was mutated for dual-luciferase reporter assays. b The mRNA levels of TDG in tissues from PTC patients (n = 96, **p < 0.001). c Association analysis of miR-107 and TDG mRNA levels in PTC tissues. d The dual-luciferase reporter gene assay showed that miR-107 decreased luciferase activity in the 3'-UTR-TDG-WT group (n = 3, **p < 0.001). e, f Relative mRNA and protein levels of TDG in B-CPAP and TPC-1 cells transfected as indicated (n = 3, **p < 0.001). g Positive correlation between HOTAIRM1 and TDG expression levels in 96 paired PTC tissues. h, i The mRNA and protein levels of TDG in cells with stable overexpression of HOTAIRM1 (n = 3, **p < 0.001). j TDG protein levels of in B-CPAP and TPC-1 cells following overexpression of HOTAIRM1 and/or enhancement of miR-107.