Mouse TGF¿ß RII APC-conjugated Antibody FAB532A-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse TGF¿ß RII APC-conjugated Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $469.00Supplier Page View Company Product Page
Catalog NumberFAB532A-100
FormatSupplied in a saline solution containing BSA and Sodium Azide
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse TGF¿ß RII and S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF¿ß RII, Ile24-Asp184, Accession # Q62312
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageProtect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
ReactivityMouse (Ms)
ClonalityPolyclonal
NCBI Gene AliasesRIIDN, TbetaR-II, 1110020H15Rik, TBR-II, TbetaRII, DNIIR
NCBI Full Gene Nametransforming growth factor, beta receptor II
ApplicationsFlow Cytometry (FCM)
HostGoat
IsotypeIgG
TargetTGF-beta RII
Conjugate/TagAllophycocyanin
Quantity100 Tests (also 25 Tests)

Specifications/Features

Available conjugates: Allophycocyanin

Questions and Answers

Can this antibody be used for flow cytometry applications in mouse models?

Yes, the TGF-beta RII APC-conjugated Antibody is specifically designed for use in flow cytometry applications, demonstrating effective reactivity with mouse TGF-beta RII.

What is the specificity of this antibody when used in assays?

The antibody detects mouse TGF-beta RII in direct ELISAs and Western blots, with approximately 5% cross-reactivity with recombinant human TGF-beta RII and less than 1% cross-reactivity with recombinant mouse TGF-beta RI and human TGF-beta RIII.

What type of immunogen was used to generate this antibody?

The TGF-beta RII APC-conjugated Antibody was generated using a recombinant mouse TGF-beta RII derived from a mouse myeloma cell line (NS0) and an insect ovarian cell line (Sf 21), specifically targeting the region Ile24-Asp184.

How should this antibody be stored to maintain its stability?

The antibody should be protected from light and stored at 2 to 8 °C. It is stable for 12 months from the date of receipt and should not be frozen.

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell FunctionCancer researchMay 16, 2022Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim DS, Pytel D, Kang I, Nadig SN, et al.

(2) CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in miceCell death and differentiationJanuary 1, 2022Hu M, Lu Y, Wang S, Zhang Z, Qi Y, Chen N, Shen M, Chen F, Chen M, Yang L, et al.

(3) Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8⁺ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-βImmunityJuly 14, 2020Borges da Silva H, Peng C, Wang H, Wanhainen KM, Ma C, Lopez S, Khoruts A, Zhang N, Jameson SC.

(4) Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signalingThe Journal of clinical investigationApril 3, 2017Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, et al.

(5) TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responsesNature communicationsFebruary 19, 2015Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, et al.

(6) MicroRNAs are implicated in the suppression of CD4+CD25− conventional T cell proliferation by CD4+CD25+ regulatory T cellsMolecular immunologyFebruary 1, 2015Zhou S, Dong X, Zhang C, Chen X, Zhu J, Li W, Song X, Xu Z, Zhang W, Yang X, et al.

(7) Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesisThe Journal of clinical investigationJanuary 1, 2014Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, et al.

(8) PARP-1 regulates expression of TGF-β receptors in T cellsBloodSeptember 26, 2013Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, et al.

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TGF-beta RII APC-conjugated Antibody

TGF-beta RII APC-conjugated Antibody

TGF-beta RII APC-conjugated Antibody

Mouse TGF¿ß RII APC-conjugated Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

Citations (8)

Reviews

Mouse TGF¿ß RII APC-conjugated Antibody from R&D Systems, a Bio-Techne Brand

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