BIOCARE MEDICAL's p63 + p504S (PIN) Antibody is a Mouse, and Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
P504S is an enzyme in the ß-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. p63, a homolog of the tumor suppressor p53, encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. Expression of p63 is detected in prostate basal epithelial nuclei in normal prostate; however, is negative in malignant tumors of the prostate gland. p63 P504S antibody may be an extremely useful aid in diagnosing prostatic intraepithelial neoplasia (PIN), especially in difficult and limited tissues cases