Fig 1: Microbiome studies and IHC. (A) Procession of the input reads throughout the dada2 workflow of the microbiome analysis. (C) Analysis of ß-diversity using unweighted (left) or weighted Unifrac analysis. (C) Depiction of all significant log2 fold changes in taxonomic abundance from different taxonomic levels. (D) Representative IHC stainings of ENT1 on mouse tissue section of DSS- and vehicle-treated animals in the presence or absence of tofacitinib (left) with the quantification displayed as graph (right). (E) Representative IHC stainings of pSTAT3 on mouse tissue section of DSS- and vehicle-treated animals in the presence or absence of tofacitinib (left) with the quantification displayed as graph (right). dF, denoised forward; dR, denoised reverse; NMDS, nonmetric multidimensional scaling.