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Antibodies
Anti-C5b-9 + C5b-8 antibody [aE11]
Anti-C5b-9 + C5b-8 antibody [aE11] from Abcam
(1)
Write a review
Citations:
(20)
Supplier Page
Supplier Page from
Abcam for
Anti-C5b-9 + C5b-8 antibody [aE11]
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-C5b-9 + C5b-8 antibody [aE11]
Company
Abcam
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
ab66768
Isotype
IgG2a
Quantity
100 UL
Clonality
Monoclonal
Clone
aE11
Host
Mouse, Nude mouse
Conjugate/Tag
Unconjugated
Applications
Immunohistochemistry-frozen (IHC-fr)
Concentration
1 mg/ml
Gene Name
C9
Reactivity
Human
Target
C5b-9
Antibody Type
Primary
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (20)
(1)
Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa
PLOS Pathogens
January 25, 2023
Manon Janet-Maitre, Stéphane Pont, Frerich M. Masson, Serena Sleiman, Julian Trouillon, Mylène Robert-Genthon, Benoît Gallet, Chantal Dumestre-Perard, Sylvie Elsen, Christine Moriscot,
et al.
membrane
deposition/insertion was detected with
mouse
monoclonal
anti-C5b-9
antibody (8 μg/mL,
Abcam
#
ab66768
). Antibody binding was revealed with PE-conjugated
goat
anti-
mouse
antibodies (2.5 μg/mL,
Abcam
#
ab97041
).
(2)
The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies
Acta Neuropathologica Communications
December 1, 2022
Nicole Becker, Steven A. Moore, Karra A. Jones
using HLA-ABC (MHC class I; Agilent (DAKO);
clone
W6/32;
1:25
) and complement C5b-9 (
Abcam
;
clone
aE11;
ab66768
;
1:50
). All H&E and immunostained slides were digitally scanned at 20× magnification using the 3DHistech
(3)
Miyoshi Muscular Dystrophy Due to Novel Splice Site Variants in DYSF Gene
Child Neurol Open
November 16, 2022
Grace Bryant, Steven A. Moore, James S. Nix, Grace Rice, Murat Gokden, Aravindhan Veerapandiyan
expression was patchy (HLA-ABC; Agilent (DAKO);
clone
W6/32), and C5b-9 deposits (
Abcam
;
clone
aE11;
ab66768
) were identified on
muscle
fiber surfaces
by immunofluorescence
. Taken together, the neuropathologic
(4)
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages
Frontiers in Immunology
September 27, 2022
Gisela Jimenez-Duran, Joseph Kozole, Rachel Peltier-Heap, Eleanor R. Dickinson, Christopher R. Kwiatkowski, Francesca Zappacosta, Roland S. Annan, Nicholas W. Galwey, Eva-Maria Nichols, Louise K. Modis,
et al.
Alexa Fluor® 546 conjugate",
Thermo-Fisher
,
A10040
Biotinylated C5b-9,"(
Abcam
, biotinylated in-house)",
ab66768
Ruthenylated
anti-C6
,"(
Quidel
, ruthenylated in-house)",
A219
"Chemicals, Peptides, and Recombinant
(5)
Cd59 and inflammation regulate Schwann cell development
eLife
June 24, 2022
Ashtyn T Wiltbank, Emma R Steinson, Stacey J Criswell, Melanie Piller, Sarah Kucenas
neurofascin 186; also referred to as NF186" Antibody,Anti-C5b-8+C5b-9 (
mouse
monoclonal),
Abcam
,Cat#
ab66768
,"(
1:500
), C5b-8+C5b-9; also referred to
membrane
attack complex or MAC" Antibody,Alexa Fluor 488 anti-chicken
(6)
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
Nature Medicine
February 17, 2022
Thomas Senage, Anu Paul, Thierry Le Tourneau, Imen Fellah-Hebia, Marta Vadori, Salam Bashir, Manuel Galiñanes, Tomaso Bottio, Gino Gerosa, Arturo Evangelista,
et al.
monoclonal antibody against
human
C5b-9 was obtained from
Abcam
(
clone
aE11, 10 μg ml−1; catalog no.
AB66768
). All antibodies were used at optimized saturating conditions.
Avidin/biotin blocking kit
was obtained
(7)
C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett's Esophagus and Esophageal Adenocarcinoma
Frontiers in immunology
January 1, 2022
Kolka CM, Webster J, Lepletier A, Winterford C, Brown I, Richards RS, Zelek WM, Cao Y, Khamis R, Shanmugasundaram KB,
et al
.
C9 rabbit polyclonal (Sigma #4503059) diluted
1:1000
and C5b-9
mouse
monoclonal
clone
aE11 (
Abcam
#
ab66768
), targeted against a C9 neoepitope, diluted
1:2000
was applied for 30min at room temperature. For visualization
(8)
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice
Journal of Clinical Investigation
April 1, 2021
Sara A. Healy et al.
minutes and the pellet was then incubated with 10 μg/mL of the mAb
anti-C5b-9
+ C5b-8 (
Abcam
, catalog
ab66768
) for 2 hours on ice. Cells were washed with PBS, centrifuged at 500g for 5 minutes, and stained with
(9)
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Nature Communications
March 19, 2021
Camila H. Coelho et al.
× g for 5 min, and the pellet then incubated with 10ug/mL of the mAb
anti-C5b-9
+ C5b-8 (
Abcam
, ref
ab66768
) for 2 h on ice. Cells were washed with PBS, centrifuged at 500 × g for 5 min, stained with Hoechst
(10)
The conundrum of postpartum thrombotic Microangiopathy: case report and considerations for management
BMC Nephrology
December 1, 2019
Katharina Artinger, Gerald Hackl, Gernot Schilcher, Florian Eisner, Marion J. Pollheimer, Christoph Mache, Eva-Christine Weiss, Kathrin Eller, Philipp Eller
complement antibody (F0201, DAKO, Glosturp, Denmark) and monoclonal
mouse
anti-
human
C5b-9 antibody
(
ab66768
,
Abcam
, Cambridge, MA, USA), followed by secondary antibody
incubation
with Rhodamine (TRITC)-conjugated
(11)
Early auto-immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis
EMBO molecular medicine
November 1, 2018
Dembla M, Kesharwani A, Natarajan S, Fecher-Trost C, Fairless R, Williams SK, Flockerzi V, Diem R, Schwarz K, Schmitz F.
complex (TCC; Fluiter et al, 2014; Michailidou et al, 2015). This antibody was obtained from
Abcam
(#
ab66768
;
clone
αE11) and used for
immunofluorescence microscopy
in a
1:50
dilution. Additional primary antibodies
(12)
Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth
Frontiers in Immunology
November 20, 2017
Chiara Agostinis et al.
(13)
Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration
Molecular vision
January 1, 2016
Rohith R Mohan, Andrea P Cabrera, Reed E S Harrison, Ronald D Gorham, Lincoln V Johnson, Kaustabh Ghosh, Dimitrios Morikis
(14)
Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59
The Journal of Gene Medicine
November 9, 2015
Derek Leaderer, Siobhan M. Cashman, Rajendra Kumar-Singh
cells, cells were incubated for 2.5 hours at room temperature with
mouse
anti-
human
C5b-9 (
1:100
) (
ab66768
,
Abcam
, Cambridge MA) in 0.05% triton containing 6% normal
goat
serum (
NGS
). Cy3 conjugated
goat
anti
(15)
Topical Application of PPADS Inhibits Complement Activation and Choroidal Neovascularization in a Model of Age-Related Macular Degeneration
PLoS ONE
October 9, 2013
Kerstin Birke, Erion Lipo, Marco T. Birke, Rajendra Kumar-Singh
serum, 0.5% Triton X-100, 1x PBS (blocking solution). MAC was labeled with a
mouse
anti-C5b9 antibody (
ab66768
,
Abcam
, Cambridge, MA diluted
1:100
in blocking solution) and detected with a Cy3conjugated
goat
anti-
mouse
(16)
Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States
Clinical and vaccine immunology : CVI
October 1, 2013
Estela Trebicka, Susan Jacob, Waheed Pirzai, Bryan P Hurley, Bobby J Cherayil
(17)
Full functional activity of SSL7 requires binding of both complement C5 and IgA
Immunology and cell biology
August 1, 2013
Natalie Lorenz, Fiona Clow, Fiona J Radcliff, John D Fraser
(18)
Initial pulmonary respiration causes massive diaphragm damage and hyper-CKemia in Duchenne muscular dystrophy dog
Scientific reports
January 1, 2013
Nakamura A, Kobayashi M, Kuraoka M, Yuasa K, Yugeta N, Okada T, Takeda S.
St Louis, MO, USA), CD11b (
MCA1777S
,
AbD Serotec
, Oxford, UK), CD18 (
MCA1780
,
AbD Serotec
), C5b-9 (
ab66768
,
Abcam
, Cambridge, UK), cleaved
caspase 3
(#
9661
,
Cell Signaling Technology
, Beverly, MA, USA),
LC3
(19)
Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs
PloS one
January 1, 2012
Burcin Ekser, Edwin Klein, Jing He, Donna B Stolz, Gabriel J Echeverri, Cassandra Long, Chih Che Lin, Mohamed Ezzelarab, Hidetaka Hara, Massimiliano Veroux, David Ayares, David K C Cooper, Bruno Gridelli
(20)
Decay Accelerating Factor (CD55)–Mediated Attenuation of Complement: Therapeutic Implications for Age-Related Macular Degeneration
Investigative Opthalmology & Visual Science
December 1, 2010
Kelly N. Ma, Siobhan M. Cashman, J. Harry Sweigard, Rajendra Kumar-Singh
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Reviews
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(1)
12/2/2014
FFPE Immunohistochemistry of C5b-9
Mike Campa
Activation of the complement system ultimately leads to the formation of the membrane attack complex, or MAC. The MAC is composed of the complement components C5b, C6, C7, C8, and multiple copies of ...
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Anti-C5b-9 + C5b-8 antibody [aE11] from Abcam
Supplier Page
View Company Product Page
Pricing Info
Product Specs
Company Info
Citations
Reviews
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