Description
Product Characteristics:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.Tissue specificity: Widely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
Subcellular location: Cytoplasm, Nucleus
Synonyms: PKU alpha, PKU-alpha, Serine/threonine kinase, Serine/threonine protein kinase tousled like 2, Serine/threonine-protein kinase tousled-like 2, TLK 2, TLK-2, tlk2, TLK2_HUMAN, Tousled like kinase 2, Tousled-like kinase 2, MGC44450.
Target Information: The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]