Description
Product Characteristics:
NPR2L is homologous to yeast nitrogen permease and is a candidate tumor suppressor, being a negative regulator of cell cycle. Most abundant in skeletal muscle, followed by brain, liver, and pancreas, with lower amounts in lung, kidney, placenta, and heart. Expressed in most lung cancer cell lines tested. There are two isoforms, produced by alternative splicing.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: G21 protein, Gene 21 protein, Homologous to yeast nitrogen permease candidate tumor suppressor, Homologous to yeast nitrogen permease, NPR 2L, NPR L2, NPR like 2, NPR2 like, NPRL 2, NPRL2, Tumor suppressor candidate 4, TUSC 4, TUSC 4 protein, TUSC4, TUSC4 protein, NPRL2_HUMAN.
Target Information: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs