Description
Product Characteristics:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Subcellular location: Cytoplasm
Synonyms: TG2, TGC, GNAH, HEL-S-45, G-ALPHA-h, Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2
Target Information: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]