Description
Product Characteristics:
LIM domain only 3 (LMO3) belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. It is transcribed mainly in the brain. It interacts with the neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
Subcellular location: Cytoplasm
Synonyms: DAT 1, DAT1, LIM domain only 3 rhombotin like 2, LIM domain only protein 3, LMO 3, LMO3, Neuronal specic transcription factor DAT1, RBTN 3, RBTN3, RBTNL 2, RBTNL2, RHOM 3, RHOM3, Rhombotin 3, Rhombotin like 2, Rhombotin3, LMO3_HUMAN.
Target Information: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions\, thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]