Description
Product Characteristics:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular location: Nucleus
Synonyms: 14-3-3, mitochondrial import stimulation factor L subunit, protein kinase C inhibitor protein-1, Protein kinase C inhibitor protein1, Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, tyrosine 3/tryptophan 5 -monooxygenase activation protein.
Target Information: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]