Description
Product Characteristics:
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Subcellular location: Cytoplasm, Nucleus
Synonyms: CIAP 2, CIAP-2, Inhibitor of apoptosis protein 1, AIP 1, AIP1, API 2, API2, Apoptosis inhibitor 2, Baculoviral IAP repeat containing 3, Baculoviral IAP repeat containing protein 3, Baculoviral IAP repeat-containing protein 3, BIRC 3, BIRC3, BIRC3_HUMAN, C IAP2, C-IAP2, CIAP 2, CIAP2, HAIP 1, HAIP1, HIAP 1, HIAP-1, HIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, MALT 2, MALT2, Mammalian IAP homolog C, MIHC, RING finger protein 49, RNF49, TNFR2 TRAF signaling complex protein 1, TNFR2 TRAF signalling complex protein, TNFR2-TRAF-signaling complex protein 1.
Target Information: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]