Description
Product Characteristics:
MRP5 (190-200 kDa) is closely related to MRP4, both lacking the first five membrane spanning regions. MRP5 is a GS-X multi specific organic anion pump (nucleotide analogs). MRP5 may transport DNP-GS and may be inhibited by certain inhibitors of organic anion transport (sulfinpyrazone). MRP5 may also transport organic anions with the anionic moiety of phosphate/phosphonate group, a function which provides the ability to resist against anti cancer drugs 6-MP and thioguanine as well as the anti-HIV drug PMEA.
Subcellular location: Cell membrane
Synonyms: Multidrug Resistanec-Associated Protein 5, ABC 33, ABC33, ABCC 5, ABCC5, ATP binding cassette sub family C CFTR/MRP member 5, ATP binding cassette sub family C member 5, Canalicular multispecic organic anion transporter C, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP 5, Multi specic organic anion tranporter C, pABC 11, pABC11, SMRP, MRP5_HUMAN.
Target Information: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected\, however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]