Description
Product Characteristics:
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Subcellular location: Secreted, Extracellular matrix
Synonyms: NTN1L, Netrin-1, Epididymis tissue protein Li 131P, NTN1
Target Information: Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined\, however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]