Description
Product Characteristics:
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012].
Subcellular location: Nucleus
Synonyms: ELK1 phospho T417, Elk-1Thr417, p-ELK1 T417, p-Elk-1Thr417, ELK 1, ELK1 member of ETS oncogene family, ELK1 protein, ELK2 member of ETS oncogene family, ETS domain containing protein Elk 1, ETS domain containing protein Elk1, ETS domain protein Elk1, Oncogene Elk1, ETS domain-containing protein Elk-1 isoform a, ETS domain-containing protein Elk-1, ETS-like gene 1, tyrosine kinase ELK1 oncogene, ELK1_HUMAN.
Target Information: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]