Description
Product Characteristics:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Subcellular location: Cytoplasm
Synonyms: SYPphospho Y81, SHIP2, BPTP 3, BPTP3, CFC, MGC14433, Noonan syndrome 1, Noonan syndrome 1 protein tyrosine phosphatase 2C, NS 1, NS1, Protein tyrosine phosphatase 2C, Protein Tyrosine Phosphatase Non receptor Type 11, PTP 1D, PTP 2C, PTP1D, PTP2C, PTPN 11, PTPN11, SAP2, SH PTP2, SH PTP3, SH2 domain containing protein tyrosine phosphatase 2, SHIP2, SHP 2, SHP-2, SHPTP 2, SHPTP2, SHPTP3, SIT protein precursor, Syp, Tyrosine protein phosphatase non receptor type 11, Src homology 2 SH2 domain containing phosphotyrosinephosphatase 2.
Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]