Description
Product Characteristics: CD45RA recognizes Mr. 220-kDa of the leucocyte antigen (LCA). CD45RA antigen is a member of the CD45 antigen family that also includes CD45, CD45RO, and CD45RB antigens. CD45RA is expressed on approximately 75% of CD8 lymphocytes and 50% of CD4 lymphocytes, all B cells and NK Cells. CD45RA antigen is expressed on naive T lymphocytes, antigen density decreases upon in vitro activation. A decrease antigen density has been demonstrated for CD4+CD45RA+subset with active multiple sclerosis.
Target Information: member of a family of heavily glycosylated leukocyte cell surface glycoproteins\, displays extensive O-glycosylation [RGD, Feb 2006]