Description
Product Characteristics:
TPX2 is essential for spindle pole and mitotic spindle formulation, playing a role in the S and G2 phases of mitosis. It is also critical for the function of protein kinase Aurora A. TPX2 autophosphorylates Aurora A, targeting it to the spindle apparatus and allowing it to function in eukaryotic meiotic and mitotic cell cycles. TPX2 has also been found to be highly expressed in cancer cells.
Subcellular location: Cytoplasm, Nucleus
Synonyms: C20ORF1, C20orf2, Chromosome 20 Open Reading Frame 1, Dferentially expressed in cancerous and non-cancerous lung cells 2, Dferentially expressed in cancerous and noncancerous lung cells 2, Dferentially expressed in lung cells 2, Dferentially expressed in lung cells, DIL 2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA 519, HCA519, HCTP 4, HCTP4, Hepatocellular carcinoma associated antigen 519, Hepatocellular carcinoma-associated antigen 519, p100, Preferentially expressed in colorectal cancer, Protein FLS353, REPP 86, repp86, Restricted expression proliferation associated protein 100, Restricted expression proliferation-associated protein 100, Targeting protein for XKLP2, TPX 2, TPX2, TPX2 microtubule associated homolog, TPX2 microtubule associated protein homolog, TPX2_HUMAN.
Target Information: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity)