Description
Product Characteristics:
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Subcellular location: Secreted
Synonyms: IGF-II, PP9974, C11orf43, Insulin-like growth factor II, Somatomedin-A, IGF2, PP1446
Target Information: a mitogenic growth factor\, may have a role in fetal development [RGD, Feb 2006]