Description
Product Characteristics:
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.Tissue specificity:Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Subcellular location: Cytoplasm, Nucleus
Synonyms: MAP kinase 13, MAP kinase p38 delta, MAPK 13, MAPK13, MGC99536, Mitogen activated protein kinase 13, Mitogen activated protein kinase p38 delta, Mitogen-activated protein kinase 13, Mitogen-activated protein kinase p38 delta, MK13_HUMAN, p38 delta, p38delta, PRKM13, Protein kinase mitogen activated 13, SAPK 4, SAPK4, Stress activated protein kinase 4, Stress-activated protein kinase 4.
Target Information: This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]