Description
Product Characteristics:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
Subcellular location: Cytoplasm
Synonyms: TPRH, TRPH, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPH1, TPH
Target Information: catalyzes the conversion of l-tryptophan to 5-hydroxy-l-tryptophan\, member of pterin-dependent aromatic amino acid hydroxylase family [RGD, Feb 2006]