Description
Product Characteristics:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subcellular location: Cytoplasm, Nucleus
Synonyms: AI118493, DNA for thyroid hormone receptor binding site 258bp, P2R3A_HUMAN, PP2A subunit B B72/B130 isoforms, PP2A subunit B isoform PR72/PR130, PP2A subunit B isoform R3 isoform, PP2A subunit B isoforms B72/B130, PP2A subunit B PR72/PR130 isoforms, PP2A subunit B R3 isoform, PPP2R3, Ppp2r3a, PR130, PR59, PR72, Serine/threonine protein phosphatase 2A 72/130 kDa regulatory subunit B, Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B.
Target Information: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]