Description
Product Characteristics:
ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.
Subcellular location: Cytoplasm, Nucleus
Synonyms: 136 kDa double stranded RNA binding protein, Adar 1, ADAR, Adar1, Adenosine deaminase RNA specic 1, Adenosine deaminase RNA specic, Adenosine deaminase that act on RNA, AV242451, Double stranded RNA specic adenosine deaminase, Double-stranded RNA-specic editase Adar, Drada, Dsh, Dsrad, dsRNA adenosine deaminase, EC 3.5.4.-, G1P1, I 4, I4, i4 protein, Interferon induced protein 4, Interferon inducible protein 4, K88dsrbp, mZaADAR, p136, Pre-mRNA adenosine deaminase, RNA adenosine deaminase 1, RNA-editing deaminase 1, RNA-editing enzyme 1.
Target Information: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]