Description
Product Characteristics:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P45 XIB.
Subcellular location: Cytoplasm
Synonyms: FHI, CPN1, CYP11B, P45C11, Cytochrome P45 11B1, mitochondrial, CYPXIB1, Cytochrome P-45c11, Cytochrome P45C11, Steroid 11-beta-hydroxylase, CYP11B1, S11BH
Target Information: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]