Description
Product Characteristics:
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Subcellular location: Cytoplasm, Nucleus
Synonyms: HIV 1 Rev binding protein, RAB, Rev/Rex activation domain-binding protein, RIP, AGFG1, AGFG1_HUMAN, Arf-GAP domain and FG repeats-containing protein 1, ArfGAP with FG repeats 1, HIV-1 Rev-binding protein, HRB, Nucleoporin like protein RIP, Nucleoporin-like protein RIP, Rev interacting protein, Rev-interacting protein.
Target Information: The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]