Description
Product Characteristics:
Nucleostemin is a protein found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell cycle progression in stem cells and cancer cells.
Subcellular location: Nucleus
Synonyms: E2 induced gene 3 protein, E2IG3, Estradiol induced nucleotide binding protein, GNL3, Guanine nucleotide binding protein like 3 nucleolar, Guanine nucleotide binding protein like 3, MGC800, NNP47, Novel nucleolar protein 47, NS, Nucleolar GTP binding protein 3, Nucleostemin, Putative nucleotide binding protein estradiol induced, C77032, GNL3_HUMAN.
Target Information: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]