Description
Product Characteristics:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Subcellular location: Cytoplasm, Nucleus, Secreted, Cell membrane
Synonyms: EGFRTyr1110, EGFR, Avian erythroblastic leukemia viral v erb b oncogene homolog, Avian erythroblastic leukemia viral verbb oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGF R, EGFR, Epidermal growth factor receptor avian erythroblastic leukemia viral v erb b oncogene homolog, Epidermal growth factor receptor erythroblastic leukemia viral v erb b oncogene homolog avian, Epidermal growth factor receptor, erbb 1, Erbb, Erbb1, HER1, mENA, Oncogene ERBB, PIG61, Receptor tyrosine protein kinase ErbB 1, Receptor tyrosine protein kinase ErbB1, Urogastrone, wa2, Wa5.
Target Information: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]