Description
Product Characteristics:
Phospholipase A2 activator protein (PLAP), activates PLA2 (phospholipase A2 enzyme) and is an important mediator of eicosanoid generation. Also known as a pro-inflammatory agent, PLAP has been found in inflamed tissues and synovial fluid from patients with rheumatoid arthritis. As such, it is believed to play an important role in the regulation of inflammatory diseases. The formation of PLAP can be stimulated by IL-1 beta and TNF-alpha.
Subcellular location: Nucleus
Synonyms: DOA1, PLAP, PLA2P, Phospholipase A-2-activating protein, PLAA
Target Information: may play a role in phospholipase activation, production of prostaglandins, and regulation of inflammatory response [RGD, Feb 2006]