Description
Product Characteristics:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Subcellular location: Nucleus
Synonyms: Antigen p25, Cbx 5, Cbx5, CBX5_HUMAN, CG8409, Chromobox homolog 5 Drosophila HP1 alpha, Chromobox homolog 5 HP1 alpha homolog Drosophila, Chromobox homolog 5 HP1 alpha homolog, Drosophila, chromobox homolog 5, HP1 alpha homolog, Chromobox protein homolog 5, Chromobox protein homologue 5, Heterochromatin protein 1 alpha, Heterochromatin protein 1, Heterochromatin protein 1, HP 1, HP 1A, HP1 alpha homolog, HP1, HP1A, HP1Hs alpha, Suvar205, HP1a, HP1Hs-alpha, HP1 alpha, Antigen p25, Heterochromatin protein 1 homolog alpha.
Target Information: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]