Description
Product Characteristics:
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.
Subcellular location: Cell membrane
Synonyms: Ly69, Integrin beta-7, Integrin beta-P, M290 IEL antigen, Itgb7
Target Information: mediates adhesion to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) [RGD, Feb 2006]