Description
Product Characteristics:
Kallikrein 11 has two alternative splicing isoforms, known as the brain type and prostate type. Elevated serum levels of hK11 have been found in 70 % of women with ovarian cancer and in 60 % of men with prostate cancer. Analysis of this biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.
Subcellular location: Cytoplasm, Secreted
Synonyms: Hippostasin, hK11, KLK 11, KLK-11, kallikrein 11, Kallikrein 11 isoform 1 preproprotein, Kallikrein 11 isoform 2 precursor, Kallikrein 11 precursor, kallikrein related peptidase 11, KLK 11, KLK11, Protease serine 20 trypsin like, Protease serine trypsin like, PRSS20, Serine protease 20, TLSP, Trypsin like protease, KLK11_HUMAN.
Target Information: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]