Description
Product Characteristics:
MPG (N-methylpurine DNA glycosylase, or 3-methyladenine (3MeA) DNA glycosylase) repairs the 3MeA lethal lesion blocking DNA replication in Escherichia coli. Analysis of human cDNA libraries found a cDNA that would hybridize to human genomic DNA but not to E. coli or yeast DNA. This MPG gene has been mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines.
Subcellular location: Nucleus
Synonyms: N-methylpurine-DNA glycosylase isoform a, DNA 3 methyladenine glycosylase, 3 alkyladenine DNA glycosylase, AAG, ADPG, Alkyladenine DNA glycosylase, anpg, APNG, MDG, N methylpurine DNA glycosirase, CRA36.1, MDG, Mid1, PIG11, PIG16, 3MG_HUMAN.
Target Information: enzyme that cleaves 3-methyladenine and 7-methylguanine residues from DNA [RGD, Feb 2006]