Description
Product Characteristics:
CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase.
Subcellular location: Cytoplasm
Synonyms: CDCA 3, Cell division cycle associated 3, Cell division cycle associated protein 3, Gene rich cluster C8, Gene rich cluster protein C8, GRCC 8, GRCC8, MGC2577, TOME 1, TOME1, Trigger of mitotic entry 1, C8 antibody, Trigger of mitotic entry protein 1, CDCA3_HUMAN.
Target Information: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)