Description
Product Characteristics: The monoclonal antibody is directed against the CD26- antigen, which is expressed on human activated T- and B- cells. CD26 is required for T cell proliferation. It is expressed on 10-60% of resting T cells in normal peripheral blood. There is a selective decrease of CD4+ CD26+ T cells in HIV-1 infected individuals.
Target Information: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]