Description
Product Characteristics:
TLX3 (HOX11L2, RNX) belongs to a family of orphan homeobox genes that encode DNA binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine 47 replacing cytosine in the highly conserved homeodomain. This transcription factor is required for hematopoiesis. It is overexpressed in childhood acute lumphoblastic leukemia.
Subcellular location: Nucleus
Synonyms: homeo box 11-like 2, Homeobox protein Hox 11L2, HOX11 L2, HOX11L2, RNX, T cell leukemia homeobox 3, TLX-3, T cell leukemia homeobox protein 3, TLX 3, TLX3_HUMAN.
Target Information: RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]