Description
Product Characteristics:
CARF was first cloned as a novel binding partner of ARF from a yeast interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Subcellular location: Nucleus
Synonyms: Calcium response factor, CARF, CDKN2A interacting protein, CDKN2AIP, ALS2CR8, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, Calcium-response factor, CaRF, Testis development protein NYD-SP24, AL2S8_HUMAN.
Target Information: Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity)