Description
Product Characteristics: CD43, the glycoprotein leukosialin (95-115kDa MW) antigen present on all T lymphocytes and on granulocytes, monocytes and platelets in peripheral blood. The antigen is also expressed cytoplasmically by macrophages. It is also present on all immature hematopoietic cells in the bone marrow. CD43 may be involved in the regulation of B, T and NK cell function.
Target Information: The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]