Description
Product Characteristics:
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
Subcellular location: Cytoplasm
Synonyms: YWHAEphospho S58, YWHAZphospho S58, 14 3 3, 14 3 3 protein beta, 14 3 3 protein beta/alpha, 14 3 3 protein zeta, 14-3-3 protein beta/alpha, KCIP 1, Protein 1054, Protein kinase C inhibitor protein 1, YWHAB, YWHAZ, GW128, HS1, KCIP-1, YWHAE, YWHAA, 1433Z_HUMAN, Full=14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1.
Target Information: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]