Description
Product Characteristics:
Chromosomal protein HMG14 binds to the inner side of the nucleosomal DNA, thus altering the interaction between the DNA and the histone octamer and is involved in the process that maintains transcribable genes in an appropriate chromatin conformation. HMG14 has been implicated as a contributing factor in the etiology of Down syndrome.
Subcellular location: Cytoplasm, Nucleus
Synonyms: HMG14 phospho S21 + S25, High mobility group nonhistone chromosomal protein 14, High mobility group nucleosome binding 1, High mobility group nucleosome binding domain containing protein 1, High mobility group protein 14, High-mobility group nucleosome binding domain 1, HMG14, HMGN 1, HMGN1, MGC104230, MGC117425, Nonhistone chromosomal protein HMG-14, Nonhistone chromosomal protein HMG14, FLJ27265, FLJ31471.
Target Information: The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]