Description
Product Characteristics:
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Subcellular location: Secreted, Cell membrane
Synonyms: FGFBP, HBP17, FGF-BP, FGF-BP1, FGFBP-1, Fibroblast growth factor-binding protein 1, FGF-binding protein 1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, FGFBP1
Target Information: This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]