Description
Product Characteristics:
Regulates the differentiation and proliferation of normal cells through the regulation of cell death.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: BDGI, OKL38, Oxidative stress-induced growth inhibitor 1, Ovary, kidney and liver protein 38, huOKL38, Pregnancy-induced growth inhibitor OKL38, OSGIN1
Target Information: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]