Description
Product Characteristics:
SKALP
Subcellular location: Secreted
Synonyms: ELAF_HUMAN, Elafin, Elastase Specic Inhibitor, Elastase-specic inhibitor, ES 1, ESI, Peptidase inhibitor 3, PI 3, PI-3, PI3, Protease inhibitor 3 skin derived, Protease inhibitor WAP3, SKALP, Skin derived Anti leukoproteinase, Skin-derived antileukoproteinase, Trappin 2, WAP four disulfide core domain protein 14, WAP four-disulfide core domain protein 14, WFDC14.
Target Information: This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]