Description
Product Characteristics:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Protein WAVE-2, SCAR 2, SCAR, SCAR2, Verprolin homology domain-containing protein 2, WASF2, WASF2_HUMAN, WASP family protein member 2, WASP-family protein member 2, WAVE 2, WAVE2, Wiskott-Aldrich syndrome protein family member 2, Wiskott-Aldrich syndrome protein family verprolin-homologous protein, DICTYOSTELIUM, WASF2_HUMAN.
Target Information: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]