Description
Product Characteristics:
Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. FALL-39 precursor (FALL-39 peptide antibiotic, cationic anti-microbial protein, CAMP, CAP-18, HSD26) is a cathelicidin anti-microbial protein that contains the antibacterial peptide LL-37 (amino acids 134-170). In contrast to the defensins, which are cysteine-rich peptides that fold in -pleated sheets, LL-37 is a cysteine-free peptide that can adopt an amphipathic å-helical conformation. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils. The mouse and rat ortholog, CRAMP (cathelin-related antimicrobial peptide), is also part of the cathelicidin family of host defense peptides. These include precursors of potent antimicrobial peptides that direct antimicrobial activity against various microbial pathogens and also activate mesenchymal cells during wound repair. CRAMP is expressed in testis, spleen, stomach and intestine.
Subcellular location: Secreted
Synonyms: 18 kDa cationic antimicrobial protein, Antibacterial protein FALL-39, Antibacterial protein LL-37, CAMP, CAMP_HUMAN, CAP 18, CAP-18, CAP18, cathelicidin antimicrobial peptide, Cathelicidin antimicrobial peptide precursor, Cathelin-like protein, Cathelin-related antimicrobial peptide, CATHL3, Cationic antimicrobial protein CAP 18, Cationic antimicrobial protein, 18-KD, CLP, Cnlp, Cramp, CRAMP, mouse, homolog of, FALL 39, FALL 39 peptide antibiotic, FALL-39 peptide antibiotic, FALL39, hCAP 18, hCAP-18, hCAP18, HSD26, LL 37, LL37, MCLP, mcramp, Peptide antibiotic, PR-39, porcine, homolog of, SOB3.
Target Information: This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The encoded protein has several functions in addition to antimicrobial activity, including cell chemotaxis, immune mediator induction and inflammatory response regulation. [provided by RefSeq, Aug 2011]