Description
Product Characteristics:
May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
Subcellular location: Cell membrane
Synonyms: SEL1L1, PRO1063, SEL1-LIKE, Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305, UNQ128/PRO1063
Target Information: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]