Description
Product Characteristics:
Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: gamma Catenin phospho Y550, p-gamma Catenin phospho Y550, catenin cadherin-associated protein gamma 80kD, Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, Desmoplakin3, DesmoplakinIII, DP 3, DP III, DP3, DPIII, gamma catenin, Junction plakoglobin, JUP, PDGB, PKGB, PLAKOGLOBIN.
Target Information: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\, however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]